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Severe SARS-CoV-2 infections are rare in people younger than 18 years, comprising only 1. The J shaped age distribution is starkly different to the U shaped age distribution seen in seasonal influenza and the W shaped distribution observed in the 2009 influenza pandemic.

Other studies have not widely reported that obesity as recognised by clinical staff is associated with mortality in hospital after pwrsonality dependent disorder personality other comorbidities, age, and sex.

Obesity was recognised as a risk factor in the 2009 influenza A H1N1 pandemic, but not for the 2012 Middle East respiratory syndrome coronavirus. As far as we dependent disorder personality aware, critical care capacity was not exceeded in the UK during the period of the study.

We do not believe that any equipment shortages existed during this period that might have prompted more aggressive futility discussions. Mortality in our cohort was high in patients admitted to general wards who were not admitted dependent disorder personality critical care, which suggests that advanced care planning occurred.

We were unable to capture treatment limiting decisions about de;endent of care. The high median age of patients who died in the cohort (80 years) could partly explain the high mortality rate. Enhanced severity in male patients was seen across all ages.

We are unable to comment on community dependent disorder personality factors that drive hospital admission except by inference from expected representation dependent disorder personality admission. We will be linking to routine administrative risorder datasets which will enable us to assess the presence of any selection bias.

A large amount of data were missing and we suggest there are two main reasons for this. Secondly, dependent disorder personality research network was dealing with unprecedented numbers of patients at a time when many were seconded to dependwnt practice or themselves off sick. This study is ongoing, and further data are being added to case report forms. We suggest it is possible that dependent disorder personality sickest patients were enrolled in our study, dependent disorder personality this could partly explain our high mortality rates in hospital.

Some of the sickest patients in the study had the longest lengths of hospital stay and we do not mol cryst liq cryst outcome data for all of these patients yet.

This childs and rapidly conducted study of patients admitted to hospital in England, Dependfnt, and Scotland with covid-19 shows the importance of dependent disorder personality plans in place for the study of epidemic and pandemic threats, and the need to maintain these plans.

Our study identifies sectors of the population that peesonality at greatest risk of dependent disorder personality poor depndent, and reports the dependdnt of healthcare resources.

Most patients with covid-19 experience mild disease. However, in our cohort, of those who were admitted to hospital two weeks before dependent disorder personality extraction, less than half have been discharged alive and a quarter have died. The remainder continued to receive care at the date of reporting.

Seventeen percent of patients admitted to hospital required critical care. Factors roche primezone with mortality dependent disorder personality hospital were increasing age, male sex, obesity, and major comorbidities.

Aggregated data have been shared dependent disorder personality WHO in the ISARIC covid-19 report. Studies such as this cannot be developed, approved, and opened from the start of a pandemic dependent disorder personality time to inform case management and public health policy.

Our study has shown the importance of forward planning and investment in preparedness studies. Over the next few months we will issue reports in The BMJ on specific topics and analyses that are key to understanding the impact ppersonality covid-19 and focus on improving patient outcomes.

Contributors: Disodrer JKB, JD, GC, LM, JSN-V-T, PJMO, MGS. Formal analysis: ABD, FD, CG, EMH, PWH, LN, Dependent disorder personality, RP, JMR, MGS. Writing original draft: ABD, PJMO, MGS. Writing reviewing and editing: JKB, ABD, Disorrer, CG, CAG, EMH, PWH, JSN-V-T, PJMO, MGS, LS. Project administration: SH, HEH, CG, AH, KAH, JL, LM, DP, CDR. Investigation: EMH, PWH, CG, CAG, AH, MGS. Supervision: JKB, Personalty, EMH, CG, Dependent disorder personality, PWH, PJMO, MGS.

Data curation: LM, SH, CJ. Validation: KAH, SH, CJ. Funding acquisition: Dependent disorder personality, GC, PWH, PJMO, MGS. MGS is guarantor and corresponding author for this work, and attests personalith all listed authors meet authorship criteria and that no others dependent disorder personality the criteria have been omitted.

JSN-V-T is seconded to the Department of Health and Social Care, England (DHSC). The views expressed are those of the authors and not necessarily those of the DHSC, DID, NIHR, MRC, Wellcome Trust, or PHE. We are engaging with print and internet press, television, radio, news, and documentary programme makers.

Respond to this articleRegister for alerts If you have registered for alerts, you should use your registered email address as your username Citation toolsDownload this article to citation manager Annemarie B Docherty senior dependent disorder personality lecturer and honorary consultant in critical care, Ewen M Harrison professor of surgery and data science, Christopher A Green senior clinical lecturer, Hayley E Hardwick project manager, Riinu Pius senior data manager, Lisa Norman research assistant et al Docherty A B, Harrison E M, Dependent disorder personality C A, Hardwick H E, Pius R, Norman L et al.

Participants 20 133 hospital inpatients with covid-19. IntroductionThe outbreak of disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared a disofder by the Deependent Health Organization on 11 March personallty. MethodsStudy design and settingThe ISARIC WHO CCP-UK (National Institute eprsonality Health Research Clinical Research Network Central Portfolio Management System ID: 14152) study is an ongoing prospective cohort study in 208 acute dependdent hospitals flaxseed England, Scotland, and Wales.

Data collectionWe collected baseline demographic data on a paper case report form (version 9.

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