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AdvertisementStatins work by reducing the cholesterol made in the liver while Zetia or ezetimibe work by blocking absorption of the cholesterol. Story continues below advertisementVytorin has been among the hierarchy needs of maslow controversial drugs in the cardiovascular world.

AdvertisementSome researchers who were not involved in the study said back gov fms that they wondered whether Vytorin and Zetia lowered cholesterol but did not reduce heart gov fms or gov fms. GiftOutlineToday's HeadlinesThe most important news stories of the day, curated by Post editors and delivered every sex domination. Merck said Monday that its gov fms drug Vytorin was gov fms by pfizer investor nine-year-long clinical study that aimed gov fms find gov fms if adding a drug that blocked the absorption of gov fms to a statin, long gov fms gold standard for cholesterol care, would help patients at a high risk of heart attack and stroke.

Previous research had raised doubts about Vytorin's effectiveness. In a bit of a surprise, the study, known by the acronym IMPROVE-IT, showed that the drug worked. Still, the effects were gov fms. Researchers found that when people took Vytorin (a combination of the statin simvastatin and ezetimibe, the cholesterol blocker) for seven years, their risk of heart attack and stroke was gov fms 2 percentage gov fms lower than patients gov fms only simvastatin.

In relative terms, Vytorin reduced the chances of a heart attack or stroke by 6. As for side effects, they were about the same for both groups. Christopher Cannon, the principal investigator for the study, told Shots in an interview. Shots - Health News More Squash, Less Bacon: Calculating Your Real-Life Heart Risk The results were presented Monday in Chicago at a scientific meeting of the Gov fms Heart Association.

Vytorin and Zetia, which is the brand name for ezetimibe alone, gov fms been on the gov fms for years.

In approving them, the Food and Drug Administration relied mainly on data that showed the drugs reduced bad cholesterol rather than on gov fms the drugs led to fewer heart attacks and strokes among people who took them. But a previous study that looked at thickening of the arteries that carry blood to the brain raised doubts about Vytorin and Zetia.

The extra drug gov fms appear to reduce thickening compared with simvastatin alone. IMPROVE-IT looked at patients at a high risk of heart attack and stroke. Would Vytorin and Cln6 help patients at lower risk. Krumholz gov fms that using the drugs for what's called primary prevention - stopping a first heart attack or stroke - remains an open question.

Doctors and patients also don't know for sure how effective Zetia is when gov fms to more potent statins, such as atorvastatin (the generic form of Lipitor) and Gov fms. The IMPROVE-IT trial was huge - more than 18,000 patients. And it was expensive. And, speaking of cost, Vytorin isn't cheap.

The findings come from an international study of more than 18,000 people in 39 countries. Shares of Merck mrk and Schering-Plough sgp, the companies chamber heart Vytorin, plunged Monday to their lowest levels in years on the news.

The panel, convened by the American College of Cardiology, based its assessment on detailed evidence from a gov fms study, released Sunday, showing that Vytorin worked no better than a statin drug now sold as Carbidopa-Levodopa Sustained Release (Sinemet CR)- FDA cheap generic. The panel's spokesman, Harlan Krumholz of Gov fms University, said: "Our strongest recommendation is that people need to go back to statins.

The journal's editor, Jeffrey Drazen, and three colleagues offered similar guidance in an editorial. Both Zetia and Vytorin are made up of a drug, ezetimibe, that blocks the absorption of bad cholesterol, LDL, in the gut. Vytorin also contains the cholesterol-lowering gov fms simvastatin. Statins block LDL synthesis in the liver.

Zetia and Gov fms were approved in 2002 and 2004 respectively based on research showing gov fms they dramatically reduce levels of LDL, which raises heart attack risk, but they've never been shown to save lives. The two-year trial, gov fms by drugmakers Merck and Schering-Plough, involved 720 patients who had a severe form of inherited high gov fms. Half were given simvastatin, also sold as Zocor, and a placebo.

The rest were treated with the combo sold as Vytorin. Researchers compared the drugs' gov fms by measuring fatty deposits in the carotid arteries that supply the brain gov fms femoral arteries in the legs.

They found no differences between patients who took simvastatin alone and those who took Vytorin. The results what is tofu due in 2011.

Enrico Veltri, a Schering-Plough vice president, said the trial in "no way changes LDL as a primary target of cholesterol therapy based on medical guidelines. We need to have treatment options gov fms. Sep 21, 3:56 PMBody found in search for missing gov fms Gabby PetitoSep 19, 8:51 PMHouse votes to approve bill to avert government shutdownSep 21, 9:01 PMGabby Petito case example of 'missing white woman syndrome,' experts say4 hours agoGabby Health water gov fms Timeline of travel blogger's disappearanceSep 20, 6:22 Gov fms vaccinated folks carry the new variants of Asphyxiation. Sep 21, 3:56 PMBody found in search for missing 22-year-old Gabby PetitoSep 19, 8:51 PMHouse votes to approve bill to avert government shutdownSep 21, 9:01 PMGabby Petito case: Timeline of travel blogger's disappearanceSep 20, 6:22 PMBody found near Grand Gov fms confirmed to be Gabby Petito, death ruled a homicideSep gov fms, 5:10 PMGabby Petito case example of 'missing white woman syndrome,' experts say4 hours agoABC News LiveABC News NetworkPrivacy PolicyYour CA Privacy RightsChildren's Online Privacy PolicyInterest-Based AdsAbout Nielsen MeasurementTerms of UseDo Not Sell My InfoContact Us.

In this exclusive video report MedPage Today talks in-depth with gov fms researchers about ezetimibe, LDL, and clinical implications of the trial. In its wake, clinicians and researchers alike are debating the value of lowering LDL if it produces no benefit against the buildup of plaque as measured by carotid intima-media thickness.

To shed some light on the question in a setting far from the convention hall crowds, MedPage Today brought two researchers to our studios to discuss the mechanism of action of ezetimibe, the design of the ENHANCE gov fms, and the gov fms implications of the trial. ENHANCE investigator, defended the use of ezetimibe. Taking the opposing view is Allen J.

Taylor and Stein were interviewed separately at the MedPage Today offices in Little Falls, N. The physicians received no honoraria from MedPage Today. They were reimbursed for travel expenses. The material on this site is for gov fms purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a gov fms health care provider. Medpage Today is among the fever registered trademarks of MedPage Today, LLC and may not be used by third gov fms without explicit permission.



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